Measurable disease on baseline imaging per RECIST 1.1 criteria. ![]() Histological confirmation of Stage III (unresectable) or Stage IV cutaneous melanoma, per the American Joint Committee on Cancer 8th edition staging system.Voluntarily agree to participate by giving signed, dated, and written informed consent prior to any study-specific procedures.For Part 2 only, no more than 3 prior lines of therapy in the advanced setting for BRAF mutant and no more than 2 prior lines of therapy in the advanced setting in the BRAF wild type.Progression on most recent anti-neoplastic therapy.Prior treatment with first-generation anti-CTLA-4 therapy (for example, ipilimumab or tremelimumab) and prior treatment with anti-PD-(L)1 for at least 6 weeks.For Part 2 only, no intervening anti-cancer therapy between the last course of anti-PD-(L)1 treatment and the first dose of study treatment except for local measures (for example, surgical excision, biopsy, focal radiation therapy), or BRAF ± MEK inhibition when applicable in BRAF mutant participants.Progression must be either on treatment with anti-PD-(L)1 regimen or ≤ 12 weeks from last anti-PD-(L)1 dose in metastatic setting or ≤ 24 weeks from completion of therapy in adjuvant/ neoadjuvant setting.Prior treatment with anti-PD-(L)1 therapy (for example, pembrolizumab or nivolumab) for at least 6 weeks and radiologic progression confirmed by 2 scans at least 4 weeks apart, or if symptomatic due to progressive malignancy, then 1 scan showing progression is sufficient.To participate in the study, participants must meet all the following inclusion criteria: Why Should I Register and Submit Results?.When you no longer lose in the fight to survive, other survivors await you in coop – Online mode in adventure games lets you survive together, dealing with hardship, talking in chat and sending gifts to each other. Within days, the entire country became a radioactive wasteland – violence, hunger and disease reign here now. In 1985, the USSR collapsed before an unknown enemy. Choose the difficulty of the adventure games: sandbox, real life or online& Journey across the wilderness map in multiplayer mode Сraft system – get resources, hunt, find useful objects or weapons and create your own in survival quest! Remember everything you ever learned about chemistry and physics! It's an incredibly realistic survival quest game! Find weapons and build transport using various materials. Survive in a post-nuclear war in real simulator USSR: overcome disease, hunger and enemies! Play open world games Online too! Survive together with other players.Įxplore survival shelter and abandoned buildings. Online mode with chat, item exchange and joint fights. Mechanics, chemistry, shelter survival and much more. Multicraft, acquiring skills, hundreds of crafting recipes, lots of ammunition.Įxciting quests and helpful allies on your road to survival. Survive in the woods and hunt animals, but be careful: even rats can seriously injure you! Explore the wilderness of zombie rpg games! It's a real self-experiment, road to survival will be hard!Ĭhanging seasons, huge map of the USSR and more than 2,700 different towns and cities. ![]() ![]() Surviving hunger, zombies (like in zombie rpg games) and pandemic radiation won't give you a chance to unhurried walking. Craft all your resources: weapons, clothes, and transport. You'll have to face the real hunger games and dead characters! Monsters, thirst, countless pandemic diseases and injuries, blood-thirsty enemies – you have to fight it all in survival strategy games. Surviving after the apocalypse isn't easy. Who knows if they are even alive, or if radiation and the deadly virus have already reached them? Uncover the secret of the apocalypse and regain your memories during a walking across the huge territory of the USSR in the 1980s. You have to cross the entire country and save your family after nuclear war. Radiation, hunger and disease are all around you. How to survive in post-apocalyptic world destroyed by nuclear war and avoid radiation? How to stay alive in rpg games online? Tell after role playing game in Day R survival online!
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